Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain
نویسندگان
چکیده
منابع مشابه
A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1.
UNLABELLED The ubiquitin-binding zinc finger (UBZ) is a type of zinc-coordinating β-β-α fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. Here, we report the crystal structure of the UBZ domain of Y-family DNA polymerase (pol) η and the crystal structure of the complex between the UBZ domain of Werner helicase-interacting protein 1 (WRNIP1) and ubiquiti...
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The ubiquitin-binding zinc finger (UBZ) domain of human DNA Y-family polymerase (pol) g is important in the recruitment of the polymerase to the stalled replication machinery in translesion synthesis. Here, we report the solution structure of the pol g UBZ domain and its interaction with ubiquitin. We show that the UBZ domain adopts a classical C2H2 zinc-finger structure characterized by a bba ...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2019
ISSN: 0022-2623,1520-4804
DOI: 10.1021/acs.jmedchem.9b00988